oa South African Journal of Chemistry - Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives of Salicylic Acid and its Synthetic Intermediates
|Article Title||Synthesis and Antibacterial Activity of 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives of Salicylic Acid and its Synthetic Intermediates|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Bettache Guessas, Adil A. Othman and Zoulikha Khiati|
|Publication Date||Jan 2007|
|Pages||20 - 24|
|Keyword(s)||1,3,4-Oxadiazole-2-thione, 1H-1,2,4-triazole-5-thiol, 4-amino-1,2,4-triazole-5-thiol, Antibacterial activity and Salicylic acid|
Eight compounds 2-9 have been synthesized starting from salicylic acid, two of them (7 and 9) are novel. The four final products namely: 5-(2-hydroxy phenyl)-1,3,4-oxadiazole-2-thione 4, 3-(2-hydroxy phenyl)-1H-1,2,4-triazole-5-thiol 6, 3-(2-hydroxy phenyl)-4-amino-1,2,4-triazole-5-thiol 8 and 3-(2-hydroxy phenyl)-1-amino-1,2,4-triazole-5-thiol 9 have been prepared using known reactions. The structures of intermediates and final products were determined by spectroscopic IR, UV, 1H-NMR & MS-methods in addition to elemental analysis. Antibacterial activities of compounds 1-6 and 8 were investigated in vitro against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported herein.
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