oa South African Journal of Chemistry - Synthesis of Imidazol[1,5-]indole-1,3-diones from Imidazolidene-2,4-diones



Copper and tributyltin hydride catalysed cyclization, through the -aryl bond formation, of imidazolidine-2,4-diones (11-16, 18) yielded imidazo[1,5-]indole-1, 3-diones (5-10) in high yields (72-100%). The ease of cyclization was found to be consistent with the normal halogen reactivity and the type of substituents. The highly substituted imidazole-2,4-dione 15 gave brominated 19 and tin incorporated heterocycles 20 when treated with copper bromide and tributyltin hydride, respectively.


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