oa South African Journal of Chemistry - The Synthesis of 5-, 6-, 7- and 8-Membered Oxygen-containing Benzo-fused Rings using Alkene Isomerization and Ring-closing Metathesis Reactions



A number of benzo-fused oxygen-containing heterocycles were synthesized from allyl-3-isopropoxy-4-methoxybenzaldehyde using metathesis or an alkene isomerization-metathesis sequence as key synthetic steps. Benzo-fused compounds thus formed included a 3, 6-dihydro-1-2-benzoxocine, 1, 3-dihydro-benzo[]oxepine, 1-isochromene, 2, 3-dihydro-benzo[]oxepine, benzofuran and 2-chromene skeleton, demonstrating the versatility of this methodology.


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