oa South African Journal of Chemistry - The Synthesis of 5-, 6-, 7- and 8-Membered Oxygen-containing Benzo-fused Rings using Alkene Isomerization and Ring-closing Metathesis Reactions
|Article Title||The Synthesis of 5-, 6-, 7- and 8-Membered Oxygen-containing Benzo-fused Rings using Alkene Isomerization and Ring-closing Metathesis Reactions|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Rakhi Pathak, Jenny-Lee Panayides, Tanya D. Jeftic, Charles B. De Koning and Willem A.L. Van Otterlo|
|Publication Date||Jan 2007|
|Pages||1 - 7|
|Keyword(s)||Benzo-fused compounds, Isomerization, Ring-closing metathesis and Ruthenium|
A number of benzo-fused oxygen-containing heterocycles were synthesized from allyl-3-isopropoxy-4-methoxybenzaldehyde using metathesis or an alkene isomerization-metathesis sequence as key synthetic steps. Benzo-fused compounds thus formed included a 3, 6-dihydro-1H-2-benzoxocine, 1, 3-dihydro-benzo[c]oxepine, 1H-isochromene, 2, 3-dihydro-benzo[b]oxepine, benzofuran and 2H-chromene skeleton, demonstrating the versatility of this methodology.
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