oa South African Journal of Chemistry - Synthesis and antimicrobial activity of new α-aminophosphonic acid esters : research article

Abstract

Synthesis of new α-aminophosphonic acid esters (3a-1) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl / dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized α-aminophosphonic acid esters (3a-1) were established by elemental analysis, and IR, ¹H, ¹³C, ³¹P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.