oa South African Journal of Chemistry - Synthesis and antimicrobial activity of new α-aminophosphonic acid esters : research article
Synthesis of new α-aminophosphonic acid esters (3a-1) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl / dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized α-aminophosphonic acid esters (3a-1) were established by elemental analysis, and IR, 1H, 13C, 31P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.
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