oa South African Journal of Chemistry - Synthesis and antimicrobial activity of new -aminophosphonic acid esters : research article

Volume 61, Issue 1
  • ISSN : 0379-4350



Synthesis of new -aminophosphonic acid esters () was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl / dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized -aminophosphonic acid esters () were established by elemental analysis, and IR, 1H, 13C, 31P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity.

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