oa South African Journal of Chemistry - Synthesis and antioxidant activity of 3,3'-diselanediylbis (N,N-disubstituted indolizine-1-carboxamide) and derivatives : research article



A series of novel diselenides 5a-e were synthesized from α-haloketones, α-picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1-carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from α-picoline and chloroacetic acid by using the Tschischibabin reaction.


Article metrics loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error