oa South African Journal of Chemistry - A facile catalyst-free Pudovik reaction for the synthesis of α-amino phosphonates : research article
|Article Title||A facile catalyst-free Pudovik reaction for the synthesis of α-amino phosphonates : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||K. Reddimohan Naidu, K.R.K. Kumar Reddy, C. Vinod Kumar, C. Naga Raju and D. Divya Sharma|
|Publication Date||Jan 2009|
|Pages||185 - 188|
|Keyword(s)||5-Amino-1-naphthol, Antimicrobial activity, Dialkyl phosphite and Imines|
Some imines were synthesized by the reaction of 5-amino 1-naphthol with substituted aromatic aldehydes in ethanol under reflux conditions. Dialkyl phosphites underwent addition with aromatic imines to give novel α-amino phosphonates. All the title compounds were characterized by elemental analysis, IR, 1H, 13C, 31P NMR and mass spectral data. All the newly-synthesized compounds (4a-j) exhibited moderate antibacterial and antifungal activity.
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