oa South African Journal of Chemistry - A facile catalyst-free Pudovik reaction for the synthesis of α-amino phosphonates : research article

Volume 62, Issue 1
  • ISSN : 0379-4350



Some imines were synthesized by the reaction of 5-amino 1-naphthol with substituted aromatic aldehydes in ethanol under reflux conditions. Dialkyl phosphites underwent addition with aromatic imines to give novel α-amino phosphonates. All the title compounds were characterized by elemental analysis, IR, 1H, 13C, 31P NMR and mass spectral data. All the newly-synthesized compounds () exhibited moderate antibacterial and antifungal activity.

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