oa South African Journal of Chemistry - Synthesis and biological evaluation of some anthranilic acid and 2-phenylquinazoline-4(3H)-one analogues : research article
|Article Title||Synthesis and biological evaluation of some anthranilic acid and 2-phenylquinazoline-4(3H)-one analogues : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Mrityunjay Banerjee, Chinmoy C. Behera, Guru C. Pradhan, M. Afzal Azam and Susant K. Sahu|
|Publication Date||Jan 2009|
|Pages||134 - 142|
|Keyword(s)||Analgesic, Anti-inflammatory, Antimicrobial, Protein denaturation and Quinazolines|
In the present investigation a novel series of N-(phenyl) chalconyl anthranilic acids containing pyrazolines (4a-j), tetrahydropyrimidines (4k-o), tetrahydrothiopyrimidines (4p-t) and 2-phenylquinazolin-4(3H)-ones containing pyrazolines (8a-f), isoxazolines (8g-l), tetrahydropyrimidines (8m-r) and tetrahydrothiopyrimidines (8s-x) were synthesized and characterized by elemental analysis, FT-IR, 1H NMR and mass spectroscopy. The title compounds (4a-t) and (8a-x) were investigated for their analgesic, anti-inflammatory, antimicrobial and in vitro protein denaturation activities. Compounds 4j and 8x were identified as lead compounds with optimum analgesic, anti-inflammatory and antimicrobial activities.
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