oa South African Journal of Chemistry - Synthesis and biological evaluation of some anthranilic acid and 2-phenylquinazoline-4()-one analogues : research article

Volume 62, Issue 1
  • ISSN : 0379-4350



In the present investigation a novel series of N-(phenyl) chalconyl anthranilic acids containing pyrazolines (), tetrahydropyrimidines (), tetrahydrothiopyrimidines () and 2-phenylquinazolin-4()-ones containing pyrazolines (), isoxazolines (), tetrahydropyrimidines () and tetrahydrothiopyrimidines () were synthesized and characterized by elemental analysis, FT-IR, 1H NMR and mass spectroscopy. The title compounds () and () were investigated for their analgesic, anti-inflammatory, antimicrobial and in vitro protein denaturation activities. Compounds and were identified as lead compounds with optimum analgesic, anti-inflammatory and antimicrobial activities.

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