oa South African Journal of Chemistry - Synthesis and biological activity of some Triazolothiadiazoles : research article
|Article Title||Synthesis and biological activity of some Triazolothiadiazoles : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Ram J. Singh and Dharmendra K. Singh|
|Publication Date||Jan 2009|
|Pages||105 - 108|
|Keyword(s)||1,2,4-Triazole, Antibacterial activity, Hydrazine hydrate, Potassium dithiocarbazinate and Thiadiazole|
The synthesis of a series of novel 3-pyridyl-6-aryl-s-triazolo[3,4-b]-[1,3,4]-thiadiazoles is described. Fourteen new compounds were synthesized and characterized by spectral and elemental analyses. Some compounds were screened for antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa. Compounds containing aryl substituents at position 6 and the 1,2,4-triazole moiety at position 1 or 2 showed reasonable antibacterial activity.
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