oa South African Journal of Chemistry - KHSO-catalyzed three-component synthesis of α-aminonitriles : research article



A simple, convenient and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines and trimethyl silyl cyanide under solvent-free conditions in the presence of a catalytic amount of KHSO in good yields. The new method compares well in terms of yields with alternative methods. In general the reaction times are much shorter and the work up much easier.


Article metrics loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error