oa South African Journal of Chemistry - KHSO-catalyzed three-component synthesis of α-aminonitriles : research article

Volume 62, Issue 1
  • ISSN : 0379-4350



A simple, convenient and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes, amines and trimethyl silyl cyanide under solvent-free conditions in the presence of a catalytic amount of KHSO in good yields. The new method compares well in terms of yields with alternative methods. In general the reaction times are much shorter and the work up much easier.

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