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oa South African Journal of Chemistry - Synthesis and antimicrobial activity of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2-1,3,2λ5-benzoxazaphosphinin-2-thiones : research article

Volume 62, Issue 1
  • ISSN : 0379-4350

 

Abstract

Synthesis of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2-1,3,2λ5-benzoxazaphosphinin-2-thiones () was accomplished through a two-step process. It involves the prior preparation of 2-chloro-3-(6-methyl-2-pyridyl)-3,4-dihydro-2-1,3,2λ5-benzoxazaphosphinin-2-thione monochloride () and its subsequent reaction with the aminoacid ester hydrochlorides in dry tetrahydrofuran-toluene in the presence of triethylamine at various temperatures. These compounds were characterized by IR, 1H, 13C, 31P NMR and mass spectral data.

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/content/chem/62/1/EJC24484
2009-01-01
2017-02-22

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