oa South African Journal of Chemistry - Synthesis and antimicrobial activity of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thiones : research article
Synthesis of 2-(aminoacid ester)-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thiones (3a-j) was accomplished through a two-step process. It involves the prior preparation of 2-chloro-3-(6-methyl-2-pyridyl)-3,4-dihydro-2H-1,3,2λ5-benzoxazaphosphinin-2-thione monochloride (2) and its subsequent reaction with the aminoacid ester hydrochlorides in dry tetrahydrofuran-toluene in the presence of triethylamine at various temperatures. These compounds were characterized by IR, 1H, 13C, 31P NMR and mass spectral data.
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