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oa South African Journal of Chemistry - An environmentally friendly solvent-free synthesis of 3,4-dihydropyrimidinones using a -aminobenzene sulfonic acid catalyzed Biginelli reaction : short communication

 

Abstract

Anhydrous -aminobenzene sulphonic acid mediated solvent-free protocol is described for the synthesis of dihydropyrimidinones by the cyclocondensation of aldehydes, -ketoesters and urea/thiourea. Yields obtained are significantly higher than those obtained utilizing classical Biginelli reaction conditions.

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/content/chem/63/1/EJC24491
2010-01-01
2016-12-04
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