oa South African Journal of Chemistry - An environmentally friendly solvent-free synthesis of 3,4-dihydropyrimidinones using a p-aminobenzene sulfonic acid catalyzed Biginelli reaction : short communication
|Article Title||An environmentally friendly solvent-free synthesis of 3,4-dihydropyrimidinones using a p-aminobenzene sulfonic acid catalyzed Biginelli reaction : short communication|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Ming Shu Wu, Ping He and Xiang Zhu Zhang|
|Publication Date||Jan 2010|
|Pages||224 - 226|
|Keyword(s)||3,4-dihydropyrimidinones, Anhydrous p-aminobenzene sulphonic acid, Biginelli reaction, Hainan Normal University, China and Institute of Anyang Technology, China|
Anhydrous p-aminobenzene sulphonic acid mediated solvent-free protocol is described for the synthesis of dihydropyrimidinones by the cyclocondensation of aldehydes, β-ketoesters and urea/thiourea. Yields obtained are significantly higher than those obtained utilizing classical Biginelli reaction conditions.
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