oa South African Journal of Chemistry - Synthesis of (S)-3-Aminoethyl-1,2,3,4-Tetrahydroisoquinoline (TIQ-Diamine) via the Mitsunobu Protocol : research article
|Article Title||Synthesis of (S)-3-Aminoethyl-1,2,3,4-Tetrahydroisoquinoline (TIQ-Diamine) via the Mitsunobu Protocol : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||R.B. Kawthekar, B.K. Peters, T. Govender, H.G. Kruger and G.E.M. Maguire|
|Publication Date||Jan 2010|
|Pages||195 - 198|
|Keyword(s)||Mitsunobu reaction, Tetrahydroisoquinoline, TIQ-diamine and University of KwaZulu-Natal|
The synthesis of (S)-3-Aminoethyl-1, 2, 3, 4-tetrahydroisoquinoline (TIQ-diamine) was successfully achieved via the Mitsunobu protocol. The method from earlier reports utilizing aminolysis of commercially available TIQ-amino methyl ester, and reduction of the amide, proved to be inadequate for preparation of TIQ-diamines. The modified route requires three additional steps and consequently rendered three novel intermediates, which were furnished under mild conditions.
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