oa South African Journal of Chemistry - Euphorbias of South Africa : two new phorbol esters from Euphorbia bothae : research article
|Article Title||Euphorbias of South Africa : two new phorbol esters from Euphorbia bothae : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Wendy L. Popplewell, Eloise A. Marais, Linda Brand, Brian H. Harvey and Michael T. Davies-Coleman|
|Publication Date||Jan 2010|
|Pages||175 - 179|
|Keyword(s)||Euphorbia bothae, Euphorbiaceae, North-West University, Opioid receptor, Phorbol ester and Rhodes University|
Two known phorbol esters, 12-deoxyphorbol-13-isobutyrate-20-acetate (1) and 12-deoxyphorbol-13-(2-methylbutyrate)-20-acetate (2), and two new phorbol esters, 12-deoxyphorbol-13-isobutyrate-16-angelate-20-acetate (3) and 12-deoxyphorbol-13-(2-methylbutyrate)-16-angelate-20-acetate (4), were isolated from the endemic South African plant Euphorbia bothae. Standard spectroscopic techniques were used to elucidate the structures of all four compounds. The interaction of 1-4 with opioid receptors was explored in an attempt to explain the unexplained stupor occasionally observed in herbivores browsing on E. bothae.
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