oa South African Journal of Chemistry - The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes : research article
|Article Title||The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Rafique Ul Islam, Myron M. Johnson, Raushaan Mohammed, Justin Hean, Patrick Arbuthnot, Charles B. De Koning and Willem A.L. Van Otterlo|
|Publication Date||Jan 2010|
|Pages||88 - 94|
|Keyword(s)||Antiviral Gene Therapy Research Unit, Cationic lipoplexes, Cholesterol, Conjugates, Molecular Sciences Institute, Piperazine and Transfection|
A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.
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