oa South African Journal of Chemistry - The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes : research article



A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.


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