oa South African Journal of Chemistry - Selective bromination of 4-chloro-1-indanone and synthesis of (4-chloro-2, 3-dihydro-1-indene-2-yl)methanamine : research article

Volume 63, Issue 1
  • ISSN : 0379-4350



The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chloro-1-indanone followed by reduction gave (4-chloro-2, 3-dihydro-1-indene-2-yl)methanamine in quantitative yield.

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