oa South African Journal of Chemistry - 1,5-bis (2-hydroxyphenyl)pent-1,4-diene-3-one : a lead compound for the development of broad-spectrum antibacterial agents : research article

Volume 63, Issue 1
  • ISSN : 0379-4350



A systematic and comparative study has been made starting from a naturally-occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one () as a lead compound with potential against a panel of pathogenic bacterial strains, (coagulase negative), , , sp. and . Gentamycine and tetracycline were used as reference drugs. The mode of antibacterial action of was also studied by scanning electron microscopy, which showed membrane disruption and cell lysis of the organisms during the exposure of the tested compound. toxicity tests demonstrated that all the bioactive compounds showed far less toxicity against human erythrocytes.

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