oa South African Journal of Chemistry - 1,5-bis (2-hydroxyphenyl)pent-1,4-diene-3-one : a lead compound for the development of broad-spectrum antibacterial agents : research article
|Article Title||1,5-bis (2-hydroxyphenyl)pent-1,4-diene-3-one : a lead compound for the development of broad-spectrum antibacterial agents : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Archna Rania, Sapna Jain, Rita Kumar and Anil Kumar|
|Publication Date||Jan 2010|
|Pages||31 - 35|
|Keyword(s)||[alpha],[beta]-unsaturated carbonyl compounds, Antibacterial agent, Chalcone and MIC|
A systematic and comparative study has been made starting from a naturally-occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one (1c) as a lead compound with potential against a panel of pathogenic bacterial strains, Staphylococcus (coagulase negative), Escherichia coli, Pseudomonas aeruginosa, Acenetobacter sp. and Klebsiella pneumoniae. Gentamycine and tetracycline were used as reference drugs. The mode of antibacterial action of 1c was also studied by scanning electron microscopy, which showed membrane disruption and cell lysis of the organisms during the exposure of the tested compound. In vitro toxicity tests demonstrated that all the bioactive compounds showed far less toxicity against human erythrocytes.
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