oa South African Journal of Chemistry - Elucidation of the complex Baylis-Hillman reaction of 3-methoxy-2-nitrobenzaldehyde with methyl vinyl ketone : research article
|Article Title||Elucidation of the complex Baylis-Hillman reaction of 3-methoxy-2-nitrobenzaldehyde with methyl vinyl ketone : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 Rhodes University, 2 Rhodes University, 3 Rhodes University, 4 Rhodes University and 5 Rhodes University|
|Publication Date||Jan 2011|
|Pages||144 - 150|
|Keyword(s)||1H NMR spectroscopic analysis, Baylis-Hillman reaction, Bis-(MVK)Baylis-Hillman products, Kinetics and Mechanism|
DABCO-catalyzed reaction of 3-methoxy-2-nitrobenzaldehyde with methyl vinyl ketone (MVK) affords a mixture of products, comprising the 'normal' Baylis-Hillman adduct, the MVK dimer and a pair of diastereomeric bis-(MVK)Baylis-Hillman adducts. 1H NMR spectroscopy-based kinetic studies have provided clear insights into the competing pathways and product distribution in this complex reaction.
Article metrics loading...