oa South African Journal of Chemistry - Solventless synthesis of quinoline derivatives : acceleration of Friedländer reaction by supported heteropoly acids : research article

Volume 64, Issue 1
  • ISSN : 0379-4350



Different Keggin type heteropoly acids (HPAs) and supported ones on solids with different nature and textural properties were used in the Friedländer reaction in order to obtain quinoline derivatives. This conversion has been preceded by tungstophosphoric acid supported on silica, KSF and activated carbon as optimized catalysts in high yields and short reaction times. The general applicability of this method is demonstrated by using various substrates including ketones, β-ketoesters and β-diketones. For most substrates the reaction worked well. These catalysts were found to be reusable and considerable catalytic activity could still be achieved after the fourth run.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error