oa South African Journal of Chemistry - Microwave irradiation conventional heating in the synthesis of -methyl-2-pyrrolidone catalyzed by highly active copper powder : short communication

Volume 64, Issue 1
  • ISSN : 0379-4350



A convenient one-pot synthesis of -methyl-2-pyrrolidone is achieved either by conventional heating or microwave irradiation. The intermediate -methyl-4-hydroxybutyramide formed from the exothermic reaction of γ-butyrolactone with aqueous methylamine undergoes an intramolecular condensation reaction catalyzed by highly active copper powder to form the pyrrolidone in good yield.

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