oa South African Journal of Chemistry - SnO/SiO nanocomposite catalyzed one-pot, four-component synthesis of 2-amino-3-cyanopyridines : research article

Volume 65, Issue 1
  • ISSN : 0379-4350



An efficient and rapid protocol for the synthesis of 2-amino-3-cyanopyridines by the cyclocondensation reaction of aromatic aldehydes, methyl ketones, malononitrile and ammonium acetate catalyzed by SnO/SiO nanocomposite material at refluxed condition in ethanol was investigated. Nanocomposite (SnO/SiO) catalytic material has been synthesized by using the sol-gel method. The prepared catalytic materials were characterized by using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmer-Teller (BET) surface area, and temperature-programmed desorption of ammonia (NH-TPD). Advantages of the present method include a simple work-up procedure, high yields of the products, low toxicity and easy recovery and reusability of the catalytic materials.

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