oa South African Journal of Chemistry - Rapid synthesis of 2-substituted-2,3-dihydro-4(1)-quinazolinonesusing boric acid or sodium dihydrogen phosphateunder solvent-free conditions : research article



Two efficient and convenient methods have been described for synthesis of 2-substituted-2,3-dihydro-4(1)-quinazolinone derivatives by one-pot condensation of 2-anthranilamide with aldehydes or ketones in the presence of a catalytic amount of boric acid or sodium dihydrogen phosphate under solvent-free conditions. The attractive features of these processes are short reaction times, easy isolation of products, excellent yields and an environmental friendly procedure.


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