oa South African Journal of Chemistry - Rapid synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinonesusing boric acid or sodium dihydrogen phosphateunder solvent-free conditions : research article
|Article Title||Rapid synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinonesusing boric acid or sodium dihydrogen phosphateunder solvent-free conditions : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Author||Zahed Karimi-Jaberi and Leila Zarei|
|Publication Date||Jan 2012|
|Pages||36 - 38|
|Keyword(s)||2-anthranilamide, Boric acid, Dihydroquinazolinones, Sodium dihydrogen phosphate and Solvent-free synthesis|
Two efficient and convenient methods have been described for synthesis of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by one-pot condensation of 2-anthranilamide with aldehydes or ketones in the presence of a catalytic amount of boric acid or sodium dihydrogen phosphate under solvent-free conditions. The attractive features of these processes are short reaction times, easy isolation of products, excellent yields and an environmental friendly procedure.
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