oa South African Journal of Chemistry - Synthesis and antibacterial activity of some 5,5'-(1,4-phenylene)-bis-1,3,4-oxadiazole and bis-1,2,4-triazole derivatives as precursors of new S-nucleosides : research article
|Article Title||Synthesis and antibacterial activity of some 5,5'-(1,4-phenylene)-bis-1,3,4-oxadiazole and bis-1,2,4-triazole derivatives as precursors of new S-nucleosides : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 University of Sciences and Technology-Mohamed Boudiaf-Oran-USTO, Algeria, 2 University of Sciences and Technology-Mohamed Boudiaf-Oran-USTO, Algeria and 3 Universite Verlaine, France|
|Publication Date||Jan 2012|
|Pages||30 - 35|
|Keyword(s)||1,3,4-oxadiazole, 1H-1,2,4-triazole, Antimicrobial activity, S-nucleosides and Terephthalic acid|
Five compounds, namely 5,5'-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thiol)6 and 5,5'-benzene-1,4-diylbis(1H-1,2,4-triazole-3-thiol) 7a and its derivatives 7b-d were synthesized. Two related S-nucleosides 9 and 10 have been prepared from 6 and 7a. Some of these synthesized compounds were tested in vitro by spotting on Mueller Hinton Agar medium against some Gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis and three Gram-negative bacteria Escherichia coli, Pseudomonasaeruginosa, Pseudomonas fluorescens and compared with the known antibiotics cephalosporin (cefotaxim) and gentamycin. Compound 6 showed significant inhibitory activity against Gram-positive E. faecalis and Gram-negative E. coli bacteria while the others have shown variable inhibition activity.
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