oa South African Journal of Chemistry - Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi : research article
|Article Title||Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 Rhodes University, 2 Rhodes University, 3 Rhodes University, 4 Rhodes University, 5 Nelson Mandela Metropolitan University, 6 South African Institute for Aquatic Biodiversity and 7 University of the Western Cape|
|Publication Date||Jan 2013|
|Pages||64 - 68|
|Keyword(s)||Ascidian, Distaplia skoogi, Indole and Oxindole|
The known 3,6-dibromoindole (1), 6-bromo-3-chloroindole (2) and 6-bromo-2-oxindole (3) were isolated from the marine ascidian (sea squirt) Distapia skoogi collected from Algoa Bay, South Africa. Standard spectroscopic techniques were used to elucidate the structures of 1-3. All three compounds were found to be moderately cytotoxic to metastatic MDA-MB-231 breast cancer cells.
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