oa South African Journal of Chemistry - Microwave-assisted synthesis of some 1-1,2,4-triazol-3-one derivatives : research article

Volume 66, Issue 1
  • ISSN : 0379-4350



4-Amino-5-(methyl/ethyl)-2,4-dihydro-3-1,2,4-triazol-3-one were synthesized from the reaction of (methyl/ethyl)-ester ethoxycarbonyl hydrazone with hydrazine hydrate and then, converted to corresponding Schiff bases using 9H-fluorene-3-carbaldehyde. Ester, hydrazide and oxadiazole derivatives were synthesized starting from Schiff bases in three steps. All reactions occurred under conventional conditions and microwave irradiation. The obtained results were compared.

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