oa South African Journal of Chemistry - Synthesis of novel bibrachial lariat ethers (BiBLEs) containing [1,2,4]triazolo[3,4-][1,3,4]thiadiazines : research article

Volume 66, Issue 1
  • ISSN : 0379-4350



A practical and regioselective method for the synthesis of -diastereomers of bibrachial lariat ethers (BiBLEs) bearing ester and amide groups is reported. The novel bibrachial lariat ethers (BiBLEs) with neutral side chains were prepared by reaction of the corresponding aza-crown macrocycles with ethyl chloroacetate and chloroacetamide.

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