oa South African Journal of Chemistry - Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum : research article
|Article Title||Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 University of Stellenbosch, 2 University of Stellenbosch, 3 University of Stellenbosch, 4 University of Cape Town, 5 University of Cape Town, 6 Groote Schuur Hospital and 7 Groote Schuur Hospital|
|Publication Date||Jan 2013|
|Pages||231 - 236|
|Keyword(s)||1,2,3-triazole, 2-trichloromethylquinazoline, Copper click chemistry and Malaria|
Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 µM as the lowest inhibitory concentration.
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