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oa South African Journal of Chemistry - Synthesis, characterization and antimicrobial activity of copper(II) complexes of some ortho-substituted aniline Schiff bases; crystal structure of bis(2-methoxy-6-imino)methylphenol copper(II) complex : research article

 

Abstract

This study presents the synthesis, characterization and antimicrobial activity of copper(II) complexes of some ortho-substituted aniline Schiff bases (L1-L8). The Schiff bases and their respective copper(II) complexes were characterized by a combination of elemental analysis, infrared and UV/Visible studies. The structures of the ligands were also confirmed from 1H- and 13C-NMR spectral data. The infrared and electronic transition studies showed that the ligands are bidentate coordinating the imine nitrogen and the phenolic oxygen atoms in a planar configuration. Introduction of aqueous ammonia to the ethanolic solution of L3/L4 and Cu(OAc). HO aliquot yielded an ammonia-based complex due to the hydrolysis of the imine bond. The crystal structure of the resulting complex indicated a square planar geometry. The copper(II) ion crystallizes in the monoclinic system with a space group of P21/c having a = 10.9309, b = 4.85600, c = 17.7030, α = γ = 90 ° and β = 119.658 °. The geometry is slightly distorted from planarity with O1-Cu1-N1 bond angles of 92.19 ° and 87.8 °. The Schiff base ligands and their respective copper(II) complexes were screened for their antibacterial and antifungal activity against ATCC® 8739™*, subsp. ATCC® 6538™*, subsp. ATCC® 6633™* and ATCC® 2091™*. The o-vanillin-based ligands exhibited higher activity than the salicylaldehyde derivatives which were virtually non-active against the tested organisms.

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/content/chem/67/1/EJC150581
2014-01-01
2016-12-08
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