oa South African Journal of Chemistry - Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors : research article
|Article Title||Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 University of the Witwatersrand, 2 University of the Witwatersrand, 3 University of the Witwatersrand, 4 Stellenbosch University, 5 Stellenbosch University, 6 Stellenbosch University, 7 Technical University of Dortmund, Germany, 8 Technical University of Dortmund, Germany and 9 Technical University of Dortmund, Germany|
|Publication Date||Jan 2014|
|Pages||71 - 79|
|Keyword(s)||Anthranilic acid, EGFR, Piperazines and Small molecule kinase inhibitors|
Substituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.
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