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oa South African Journal of Chemistry - Conformational comparison of cyclic αβ tetrapeptide . αβ pentapeptide : research article

 

Abstract

The γ-turn inducing sugar α-amino acid plays an important role in the formation of well-defined secondary structures of cyclic tetra- and pentapeptide. Two tetra- and one novel pentapeptide were synthesized from a sugar α-amino acid and the conformations of the compounds were established by NMR spectroscopy (EASY-ROESY) and compared with CD spectroscopic data. Although the γ-turn conformation was dominant for both tetra- and pentapeptide according to NMR spectroscopic analysis in DMSO, the pentapeptide exhibited the presence of a second conformation. CD spectroscopic results in methanol showed that the tetrapeptides have a γ-turn conformation, while the pentapeptide has a random structure.

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/content/chem/67/1/EJC154368
2014-01-01
2016-12-08
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