1887

oa South African Journal of Chemistry - Quininium malates : partial chiral discrimination diastereomeric salt formation : research article

 

Abstract

Quinine was employed as a resolving agent for racemic malic acid. The resultant product was a quininium salt containing 75% of the -malate anion. Quinine was also crystallized with pure - and -malic acids and the structures of the resulting diastereomeric salts were elucidated. The crystal packings were analyzed in terms of their non-bonded interactions and the conformation of the quinine, which was compared with other quinine structures recorded in the Cambridge Structural Database. The results indicate that the mechanism of enantiomeric resolution is reliant upon hydrogen bonded interactions.

Loading

Article metrics loading...

/content/chem/67/1/EJC160153
2014-01-01
2016-12-08
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error