oa South African Journal of Chemistry - A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid : research article
|Article Title||A solvent-free synthesis of polyhydroquinolines via Hantzsch multicomponent condensation catalyzed by nanomagnetic-supported sulfonic acid : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 Semnan University, Iran, 2 Semnan University, Iran, 3 Semnan University, Iran, 4 Semnan University, Iran, 5 Semnan University, Iran and 6 Semnan University, Iran|
|Publication Date||Jan 2015|
|Pages||15 - 20|
|Keyword(s)||Hantzsch reaction, Heterocyclic compound, Multicomponent reaction, Nanomagnetic-supported sulfonic acid and Solvent-free conditions|
A simple and efficient procedure for the synthesis of polyhydroquinolines was developed, involving a one-pot four-component Hantzsch condensation of aromatic aldehydes, 1,3-cyclohexanediones, alkyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanomagnetic-supported sulfonic acid under solvent-free conditions. The method offers several advantages including high yields, short reaction times, a simple work-up procedure and catalyst reusability for several runs. Furthermore, easy isolation of the catalyst from the reaction mixture was enabled by use of an external magnet.
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