oa South African Journal of Chemistry - A facile and practical -toluenesulfonic acid catalyzed route to dicoumarols containing an aroyl group : research article

Volume 68, Issue 1
  • ISSN : 0379-4350



New and known dicoumarols may be efficiently synthesized employing -toluenesulfonic acid (-TSA) as a solid acid catalyst from the reaction of 4-hydroxycoumarin with aryl glyoxal in water. This method offers direct access to structurally diverse coumarin derivatives in moderate to good yields (up to 65%). A total of five new compounds were synthesized.

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