oa South African Journal of Chemistry - Synthesis and characterization of 5-substituted 1-tetrazoles in the presence of nano-TiCl.SiO : research article



Nano-TiCl.SiO was found to be an extremely efficient catalyst for the preparation of 5-substituted 1-tetrazole derivatives. Nano-TiCl.SiO is a solid Lewis-acid was synthesized by the reaction of nano-SiO and TiCl. The structure characterization of this acid was achieved with X-ray diffraction, thermogravimetric analysis and electron microscopy. The synthesis of the catalyst is simple and environmentally benign with a good yield. Furthermore, the catalyst is conveniently recoverable and was reused for at least three times. The antimicrobial activities of the synthetic compounds were also determined by both micro dilution methods as recommended by the Clinical Laboratory Standard Institute, but unfortunately did not exhibit antibacterial activities at the highest concentration (256 µL mL-1). Further studies are still needed to investigate the potential biological activities of these compounds against other diseases.


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