oa South African Journal of Chemistry - In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols : research article
|Article Title||In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols : research article|
|© Publisher:||South African Chemical Institute (SACI)|
|Journal||South African Journal of Chemistry|
|Affiliations||1 University of KwaZulu-Natal, 2 University of KwaZulu-Natal, 3 University of KwaZulu-Natal, 4 University of KwaZulu-Natal, 5 Ruder Boskovic Institute, Croatia, 6 Ruder Boskovic Institute, Croatia, 7 Ruder Boskovic Institute, Croatia, 8 Ruder Boskovic Institute, Croatia, 9 Ruder Boskovic Institute, Croatia and 10 Ruder Boskovic Institute, Croatia|
|Publication Date||Jan 2016|
|Pages||44 - 50|
|Keyword(s)||Antimicrobial activity, Naphthols, Phenols and Quinone methides|
Five groups of phenols/naphthols (42 compounds in total) were synthesized and screened against Gram-positive Staphylococcus aureus and Bacillus subtilis, Gram-negative Escherichia coli and Klebsiella pneumonia, and the fungus Candida albicans. Whereas compounds were found inactive against Gram-negative bacteria, potent activities against Gram-positive bacteria were observed. The activities correlate with the ability of molecules to form quinone methides, suggesting potential new modes of action.
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