oa CSIR Science Scope - Identifying novel mechanisms in the fight against diseases of the developing world
The CSIR's structural biology group has been involved in the clarification of the reaction mechanisms used by the enzyme glutamine synthetase (GS) for a number of years. GS is a central enzyme involved in nitrogen metabolism and catalyses the reversible conversion of L-glutamate, ATP and ammonia into L-glutamine, ADP, and inorganic phosphate. Three distinct forms of GS occur, with GSI found only in bacteria (eubacteria) and archaea (archaebacteria). GSII occurs only in eukaryotes (higher organisms) and GSIII genes have been found only in a few bacterial species.
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