n South African Pharmaceutical and Cosmetic Review - Bioequivalence is not enough : generic pharmaceuticals : news

Volume 37, Issue 5
  • ISSN : 0257-2028



The often asked question when it comes to prescribing and dispensing of medicines is, what are the points of difference if any, between original brands and generic brands containing the same active drug principles. In modern regulatory parlance the answer is: none if they're bioequivalent. This implies that comparatively, they should meet the therapeutic aim similarly in all respects. The question often posed by patients and their health care insurers or providers is, what are the cost savings and imminent risks. Cost savings may be easily quantified and risks calculated, but the latter although calculated, is not always readily predictable when brand substitution occurs.

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