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Diseases of the liver may have a significant impact on exercise capacity and physicians' recommendations for the athlete. Acute viral hepatitis is a systemic infection affecting the liver predominantly. Knowledge about the impaired hepatic function as well as hazards for other athletes especially in contact sports is mandatory for professional support. Differential diagnosis includes metabolic diseases, hereditary and autoimmune diseases as well as toxic and drug-induced alterations. The clinical spectrum of chronic hepatitis ranges from asymptomatic illness at one end to fatal hepatic failure. A close workup is recommended and the expertise of a liver centre often is essential. New drug developments allow the therapy of viral hepatitis with only minor or even without deterioration of athlete's performance. According to the severity of liver damage recommendations regarding physical exercise should be made.
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