n International SportMed Journal - The gene His472Gln polymorphism in Polish endurance athletes : original research article

Volume 14, Issue 1
  • ISSN : 1528-3356



Vascular endothelial growth factor (VEGF), which acts via receptor , is a major growth polypeptide for regulating skeletal muscle angiogenesis.

Original research concerned the genetic background of physical performance.
The aim of the study was to analyse the possible importance of the His472Gln polymorphism within the gene in endurance athletes and sedentary individuals, in order to reveal the possible relationships between genotype and physical performance.
In this study, the His472Gln polymorphism (rs1870377), derived from the gene, was studied in 176 male Polish endurance athletes of a nationally competitive standard and 161 unrelated volunteers for controls. Genotyping was carried out by PCR-RFLP. Significance was assessed by Chi square (X2) analysis.
The results revealed that the frequency of the Gln/Gln genotype (21.02% vs.10.56%; P = 0.014) and 472Gln allele (41.19% vs. 29.50%; P = 0.001) was significantly higher in the endurance-orientated athletes compared to sedentary controls.
In conclusion, our results suggest that the gene may be taken into consideration as a genetic marker in endurance-oriented athletes. However, this conclusion should be interpreted with great caution and be supported with more experimental studies on the polymorphisms in elite athletes.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error