n International SportMed Journal - Bone metabolism markers in collegiate female runners : original research article

Volume 14, Issue 3
  • ISSN : 1528-3356



Overuse osteopathy including stress fracture is a serious problem for female runners.

The purpose of this study was to investigate the bone metabolism markers in female collegiate track and field athletes with/without overuse osteopathy and sedentary control.
Cross-sectional study.
Subjects included 25 female collegiate track and field athletes (stress fracture subjects, n = 12, no-stress fracture subjects, n = 13). In addition, 16 women without exercise experience were included as a control group. The measured elements were bone strength by quantitative ultrasounds (QUS), bone metabolism markers (serum bone-specific alkaline phosphatase [BAP], circulating serum cross-linked N-telopeptide [NTx], urinary NTx, and tartrate-resistant acid phosphatase [TRAP]-5b), and estradiol.
In the the resulting analysis, both stress fracture and no-stress fracture groups showed significantly higher QUS values than the non-exercising control group (p < 0.001). Moreover, both athlete groups exhibited significantly higher TRAP-5b levels than the control group (p < 0.05). However, BAP, blood NTx, urinary NTx, and estradiol levels showed no significant differences between the three groups.
These findings suggest that TRAP-5b is a useful marker to monitor bone metabolism in the track and field athletes.

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