n International SportMed Journal - Oxidative stress status in female athletes with an IgE-dependent allergic response : original research article
|Article Title||Oxidative stress status in female athletes with an IgE-dependent allergic response : original research article|
|© Publisher:||International Federation of Sports Medicine|
|Journal||International SportMed Journal|
|Affiliations||1 University of Belgrade, Serbia, 2 University of Belgrade, Serbia and 3 University of Nis, Serbia|
|Publication Date||Jan 2014|
|Pages||298 - 307|
|Keyword(s)||Antioxidative defence, Free radicals, Immune function, Inflammation and Oxidative stress|
Background: Allergy and asthma represent important problems for athletes. Also, exercise is known to induce oxidative stress and increase in reactive oxygen species during exercise might overwhelm endogenous antioxidant defence.
Type of study: Original research concerned the oxidative stress in athletes with IgE-dependent allergic response.
Research question: The aim of the present work was to assess oxidative stress biomarkers in elite athletes with known allergy and non-allergic controls.
Methods: Based on serum IgE concentration (cut-off 100 IU/L) and findings at physical examination, 66 elite athletes were divided into two groups: with some kind of IgE-dependent allergic response (n=19) and healthy controls (n=47). The following parameters were measured: White blood cell count (WBC), Immunoglobulin E (IgE), high sensitive C reactive protein (hs-CRP), Interleukin-6 (IL-6), oxidative stress parameters (reactive oxygen metabolites - ROMs, advanced oxidation protein products - AOPP and lipid hydroperoxides - LOOH) and biological antioxidative potential - BAP.
Results: Multivariate analysis of covariance revealed that IgE-dependent allergic response contributed 16.9 % to variability of oxidative status and hs-CRP and WBC to be significant covariates. Reactive oxygen metabolites (327 ± 81 vs. 294 ± 53; P=0.047) were significantly higher in athletes with IgE-dependent allergic response and biological antioxidative potential (2314 ± 344 vs. 2484 ± 226; P=0.031) was significantly lower in this group.
Conclusions: Increased reactive oxygen metabolites and reduced antioxidant capacity in athletes with IgE-mediated allergy lead us to suppose that free radical generation could be mediated at least in part via type I hypersensitivity response.
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