Therapy should be instituted in patients who have developed end-organ damage related to hypertension, or who have high levels of systolic blood pressure. However, blood pressure lowering should be gradual and performed with caution.
Drag toxicity emergencies in the elderly are frequently a result of age-related differences in drug absorption, distribution, and elimination.
With age, heart muscle size diminishes, so that heart rate and contractility tend to slow down. At the same time, rigidity in the arterial tree increases peripheral resistance.
Suspect Parkinson's disease in patients exhibiting one or more of the following features: resting tremors, rigidity, bradykinesia, and impaired postural reflexes.