n CME : Your SA Journal of CPD - Drug-food interactions : medifile

Volume 21, Issue 11
  • ISSN : 0256-2170



Extracted from text ... 702 MEDIFILE For patients on long-term drug therapy food intake and nutritional supplementation could influence their medication's therapeutic effectiveness. Some foods can increase or decrease adverse effects since they influence the metabolism of medicines. Some medications even cause malnutrition through their actions. Factors influencing drug absorption The initial phase of gastric emptying results in the first plasma peak concentration of any drug taken with food. Peak concentration is determined by gastroin-testinal transit time. Most drugs are optimally absorbed from the small intestine. Hormones released into the stomach (e.g. cholecystokinin) lead to the retention of stomach con-tents, delaying the absorption of the drug in the duo-denum. (The total concentration of the drug absorbed may remain unchanged.) Fatty foods are ..

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