n CME : Your SA Journal of CPD - Clinical approach to dyslipidaemia : main topic

Volume 21, Issue 7
  • ISSN : 0256-2170



Dyslipidaemia is common in general practice and a major risk factor for atherosclerosis. <br>Severe hypertriglyceridaemia ( > 10 mmol/l) can cause pancreatitis and may be associated with eruptive xanthomata and lipaemic serum. <br>The assessment of dyslipidaemic patients should focus on the exclusion of secondary disorders, global evaluation of cardiovascular risk, lifestyle evaluation and identification of monogenic lipid disorders. <br>Tendon xanthomata are always pathological and are diagnostic of a monogenic lipid disorder. <br>Taking a family history is very important to identify monogenic disorders. <br>Screening the family of patients with monogenic lipid disorders will reduce the incidence of premature IHD by identifying for treatment those who are at high risk. <br>Patients with monogenic lipid disorders are at a very high risk for developing cardiovascular disease and almost all require lipid-lowering drugs. <br>Patients with clinically evident vascular disease have an LDL-cholesterol target of &lt;u&gt;&lt;&lt;/u&gt; 3 mmol/l. <br>Patients with polygenic dyslipidaemia and no vascular disease should be given lipid-lowering drugs if their calculated risk of MI is more than 20% during the next 10 years after lifestyle modification. <br>Lifestyle interventions are very effective and cheap and should be applied to all patients.

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