n CME : Your SA Journal of CPD - Secondary dyslipidaemia : main topic

Volume 21, Issue 7
  • ISSN : 0256-2170



In many populations secondary causes play a dominant role in causing dyslipidaemia and in the genesis of coronary artery disease (CAD). <br>Genes also play an important role in secondary dyslipidaemia. <br>Extremely raised total cholesterol levels ( > 15 mmol/l) are usually a manifestation of a severe hypertriglyceridaemia. <br>Poorly controlled diabetes is the commonest secondary cause of massively raised triglyceride levels. <br>Insulin resistance correlates strongly with the development of macrovascular disease. <br>In some populations the insulin resistance syndrome is the commonest phenotype seen in patients with acute coronary syndromes. <br>Type 2 diabetes may conveniently be regarded as the end result of another disease that has been present for a long time, namely insulin resistance. <br>'Pre-diabetic' insulin-resistant patients should be managed aggressively to prevent the progression of macrovascular disease.

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