n CME : Your SA Journal of CPD - Disturbances of water, electrolyte and acid-base metabolism in acute poisoning : main topic




Acid-base and potassium abnormalities are common in poisoning. <br>Poisoning should be excluded in cases of unexplained metabolic acidosis. <br>Major adverse consequences of severe acidaemia include decreased cardiac output, decreased arterial blood pressure, reduction in the threshold for cardiac dysrhythmias, and a decrease in hepatic and renal blood flow. <br>The anion gap is increased in cases of ketoacidosis, lactic acidosis, and other forms of acidosis in which organic anions are increased, as in methanol and ethylene glycol poisoning.


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