n CME : Your SA Journal of CPD - More about : the marvel of inexpensive cardiovascular drugs : thiazide diuretics

Volume 22, Issue 1
  • ISSN : 0256-2170



Extracted from text ... THE MARVEL OF INEXPENSIVE CARDIOVASCULAR DRUGS: THIAZIDE DIURETICS J A KER, MB ChB, MMed (Int), MD Professor: Department of Internal Medicine, School of Medicine, University of Pretoria The drugs in this group are called thiazides, benzothiadiazides or sulphonamide diuretics. Chlorothiazide is the No.1 prototype of the group. Chlorthalidone is slowly absorbed and therefore has a longer duration of action. These drugs inhibit sodium chloride (NaCl) re-absorption in the distal convoluted tubule. They also indirectly raise potassium excretion and decrease Ca2 excretion. They are relatively weak diuretic agents but with sustained effects. The mechanism of action of these drugs ..

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