n CME : Your SA Journal of CPD - More about : the marvel of inexpensive cardiovascular drugs : aspirin

Volume 22, Issue 1
  • ISSN : 0256-2170



Extracted from text ... THE MARVEL OF INEXPENSIVE CARDIOVASCULAR DRUGS: ASPIRIN J A KER, MB ChB, MMed (Int), MD Professor: Department of Internal Medicine, School of Medicine, University of Pretoria HOW DOES ASPIRIN WORK? Aspirin irreversibly inhibits cyclo-oxygenase (COX1 and COX2). This leads to the inhibition of thromboxane A2, rendering platelets unable to aggregate and initiate a thrombus. A dose of 100 mg aspirin will completely abolish the thromboxane A2 effect. The antiplatelet effect of aspirin is maximal within 60 minutes after a dose of 160 mg. The antiplatelet effect of a single dose of aspirin can be detected before any drug can ..

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