n CME : Your SA Journal of CPD - Autoimmunity for the GP : main article

Volume 23, Issue 10
  • ISSN : 0256-2170



Autoimmunity results from the interaction of genetic and environmental factors, where immune regulation is defective. <br>Recent advances in understanding autoimmunity have provided new strategies for immunotherapy. <br>Patients with SLE have B-cell hyperactivity and respond to B-cell depletion with rituximab monoclonal antibody. <br>Inhibition of TNF-<SPAN lang lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;a&lt;/SPAN&gt;&lt;/SPAN&gt; has proved useful in patients with severe rheumatoid arthritis and Crohn's colitis, among other autoimmune diseases, but reactivation of TB is a serious concern related to this therapy. <br>Diagnosis of rheumatoid arthritis may be facilitated by a more specific assay - detection of anti-CPP antibodies. <br>Newly described anti-nucleosomal antibodies correlate with disease activity and detection of DNA antibodies in SLE. <br>Clinicians need to be vigilant for unusual presentations of autoimmunity since these patients respond to immune suppression; examples include autoimmune pancreatitis and chronic periaortitis.

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