n CME : Your SA Journal of CPD - You are what you eat? : main topic

Volume 23, Issue 11
  • ISSN : 0256-2170



A phenotype is the physiological, structural and behavioural manifestation of a genetic and environmental interaction. <br>There are likely to be many subgroups or phenotypes of obesity, with many predisposing environmental and behavioural precedents. <br>There are some individuals, with a lean phenotype, who consume a high level of dietary fat, with a concomitantly high level of fat oxidation. <br>However, obesity is in part due to a mismatch between dietary fat intake and fat oxidation. <br>There is evidence that obese individuals have a reduced capacity to oxidise fat, and a reduced proportion of type I muscle fibres, and tend to select a diet higher in overall fat energy. <br>Exercise helps to restore fat balance by increasing fat oxidation, in particular when glycogen stores are limited. <br>Current dietary recommendations for a low-fat diet are still valid, even for various obesity phenotypes. <br>A failure of metabolic flexibility, or a capacity to utilise both lipid and carbohydrate fuels, and to move appropriately between them may be implicated in obesity and associated morbidity.

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