n CME : Your SA Journal of CPD - Progestogen use in the menopause : main topic

Volume 23, Issue 4
  • ISSN : 0256-2170



Recent publications of prospective randomised controlled trials have called into question the role of progestogen use in menopausal women. <br>Progestogens are necessary to protect the endometrium from the hyperplastic effect of oestrogen. <br>Progestogens differ markedly in their effects on different organ systems. <br>In the cardiovascular system, the less androgenic progestogens have potential advantages as regards their effect on lipid profile, direct vascular effect, insulin resistance and haemostasis. <br>By virtue of their effect on breast tissue enzymes, progestogens may increase the concentration of oestradiol in breast tissue. Progestins differ in this effect. <br>Less androgenic progestogens have a favourable effect on the apoptosis proliferation ratio in breast tissue. Individualisation of menopausal hormone therapy is important, especially in the high-risk patient.

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